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KMID : 0357920130470030227
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Korean Journal of Pathology
2013 Volume.47 No. 3 p.227 ~ p.237
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Proposal for a Standardized Pathology Report of Gastroenteropancreatic Neuroendocrine Tumors: Prognostic Significance of Pathological Parameters
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Korean Society of Pathologists
Cho Mee-Yon
Sohn Jin-Hee
Jin So-Young
Kim Hyun-Ki
Jung Eun-Sun
Kim Mi-Jung
Kim Kyoung-Mee
Kim Woo-Ho
Kim Joon-Mee
Kang Yun-Kyung
Choi Joon-Hyuk
Kang Dae-Young
Kim Youn-Wha
Choi Eun-Hee
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Abstract
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Background: There is confusion in the diagnosis and biological behaviors of gastroenteropancreatic neuroendocrine tumors (GEP-NETs), because of independently proposed nomenclatures and classifications. A standardized form of pathology report is required for the proper management of patients. Methods: We discussed the proper pathological evaluation of GEP-NET at the consensus conference of the subcommittee meeting for the Gastrointestinal Pathology Study Group of the Korean Society of Pathologists. We then verified the prognostic significance of pathological parameters from our previous nationwide collection of pathological data from 28 hospitals in Korea to determine the essential data set for a pathology report. Results: Histological classification, grading (mitosis and/or Ki-67 labeling index), T staging (extent, size), lymph node metastasis, and lymphovascular and perineural invasion were significant prognostic factors and essential for the pathology report of GEP-NET, while immunostaining such as synaptophysin and chromogranin may be optional. Furthermore, the staging system, either that of the 2010 American Joint Cancer Committee (AJCC) or the European Neuroendocrine Tumor Society (ENETS), should be specified, especially for pancreatic neuroendocrine neoplasms. Conclusions: A standardized pathology report is crucial for the proper management and prediction of prognosis of patients with GEPNET.
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KEYWORD
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Neuroendocrine tumors, Digestive system, Pathology, Staging, Grading, Prognosis
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